暑熱感作(34°)がラットの骨成長と甲状腺ホルモンに与える影響

川島 知之; 矢野 秀雄

doi:10.2508/chikusan.59.67

The Influence of Heat Exposure (34°) on Bone Growth and the Level of Thyroid Hormones in Rats

Tomoyuki KAWASHIMA, Hideo YANO

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Keywords: heat exposure, bone growth, alkaline phosphatase, acid phosphatase, thyroid function

JOURNAL FREE ACCESS

1988 Volume 59 Issue 1 Pages 67-74

DOI https://doi.org/10.2508/chikusan.59.67

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Published: January 25, 1988 Received: June 06, 1987 Available on J-STAGE: March 10, 2008 Accepted: - Advance online publication: - Revised: -
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Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Date of correction: March 10, 2008 Reason for correction: - Correction: DTRECEIVED Details: Wrong : 19871206
Right : 19870606

Date of correction: March 10, 2008 Reason for correction: - Correction: ABSTRACT Details: Wrong : The experiment was to investigate the changes of physical traits and enzyme activities in the femur and the change of thyroid hormones in blood serum after heat exposure in growing rats. Wistar strain male rats aged 6 weeks were divided into two groups and placed in temperature controlled rooms; ambient temperature 24° (group C) and 34° (group H). On days 6, 12 and 18 from the beginning of experiment, blood and femur samples were collected from
every rat. The blood samples were analyzed thyroid hormone concentrations and the femur samples were measured alkaline and acid phosphatase activities
and physical traits. The elongation of the femur was not affected but the growth in width was retarded at high ambient temperature. Bone alkaline phosphatase activity dropped substantially at the beginning of heat exposure and then became stable, while bone acid phosphatase activities were lower in group H than in group C throughout the experimental period. The changes of bone enzyme activities indicate that the retardation of bone growth in width might be related to the reduction of mineralization at the beginning of heat exposure and the following bone resorption. Thyroxine (T₄), riiodothyronine (T₃) and free thyroxine concentrations in blood serum were lower in group H than in group C. The ratio of T₃ to T₄ was not changed by heat exposure.
Right : The experiment was to investigate the changes of physical traits and enzyme activities in the femur and the change of thyroid hormones in blood serum after heat exposure in growing rats. Wistar strain male rats aged 6 weeks were divided into two groups and placed in temperature controlled rooms; ambient temperature 24° (group C) and 34° (group H). On days 6, 12 and 18 from the beginning of experiment, blood and femur samples were collected from every rat. The blood samples were analyzed thyroid hormone concentrations and the femur samples were measured alkaline and acid phosphatase activities and physical traits. The elongation of the femur was not affected but the growth in width was retarded at high ambient temperature. Bone alkaline phosphatase activity dropped substantially at the beginning of heat exposure and then became stable, while bone acid phosphatase activities were lower in group H than in group C throughout the experimental period. The changes of bone enzyme activities indicate that the retardation of bone growth in width might be related to the reduction of mineralization at the beginning of heat exposure and the following bone resorption. Thyroxine (T₄), riiodothyronine (T₃) and free thyroxine concentrations in blood serum were lower in group H than in group C. The ratio of T₃ to T₄ was not changed by heat exposure.

Date of correction: March 10, 2008 Reason for correction: - Correction: PDF FILE Details: -

Abstract

The experiment was to investigate the changes of physical traits and enzyme activities in the femur and the change of thyroid hormones in blood serum after heat exposure in growing rats. Wistar strain male rats aged 6 weeks were divided into two groups and placed in temperature controlled rooms; ambient temperature 24° (group C) and 34° (group H). On days 6, 12 and 18 from the beginning of experiment, blood and femur samples were collected from every rat. The blood samples were analyzed thyroid hormone concentrations and the femur samples were measured alkaline and acid phosphatase activities and physical traits. The elongation of the femur was not affected but the growth in width was retarded at high ambient temperature. Bone alkaline phosphatase activity dropped substantially at the beginning of heat exposure and then became stable, while bone acid phosphatase activities were lower in group H than in group C throughout the experimental period. The changes of bone enzyme activities indicate that the retardation of bone growth in width might be related to the reduction of mineralization at the beginning of heat exposure and the following bone resorption. Thyroxine (T₄), riiodothyronine (T₃) and free thyroxine concentrations in blood serum were lower in group H than in group C. The ratio of T₃ to T₄ was not changed by heat exposure.

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