Concentrations of Glucose, Nitrogenous Metabolites and Minerals in the Cerebrospinal Fluid (CSF) and Blood Plasma of Cattle

Abstract

Cerebrospinal fluid (CSF) was taken from the central canal of the lumbar spinal cord, or from the cisterna cerebellomedullaris (cisterna magna) of 61 cattles including healthy and sick excepting nervous diseases. Blood sample was taken from the jugular vein simultaneously. Plasma and CSF glucose, nitrogenous metabolites, Na, Cl, K, Ca, inorganic P (Pi) and Mg were analyzed. Concentrations of urea and creatinine were higher in lumbar CSF than in cisterna magna, and CSF glucose and uric acid showed the same tendency. Urea and creatinine levels of CSF were lower than those of plasma, and the same trends were observed in glucose and uric acid levels in reference animals. Level of CSF Cl was 1.2 times higher than of plasma. Concentrations of CSF glucose and Cl showed positive correlations with those of plasma. Sodium level was somewhat higher in CSF than in plasma. Levels of CSF K, Pi and Mg were maintained within narrow range regardless of plasma concentrations. Urea level of CSF was proportional to plasma, however, CSF creatinine and uric acid levels were maintained lower ranges regardless of those increasing in blood plasma. Strict regulations of creatinine, uric acid, K, Pi and Mg levels were confirmed in CSF of cattle.