Abstract
In the present investigations I designed to determine the relationship between experimental hypertension and NaCl-metabolism, cousidering a role of Na-factor in pathogenesis of hypertension.I devided my report in three parts as follows; I Introduction, DCA hypertension, and acute Salt-hypertension, II Chronic Salt-hypertension, III Disucussion and Summary.Then, using male albino rats, I succeeded in producing DCA hypertension and acute salt-hypertension, and investigated various clinical observations such as 17-KS in urine, blood pressure, & NaCl balance. The animals (DCA-Group) were injected with DCA 5 mg. daily or every other day. Blood pressure of rats was measured by tail plethysmograph. Thereafter, the animals were killed, and then organs were histologically investigated. Adrenals were also histochemically observed.The toxic actions of DCA were remarkably influenced by the presence of the sodium chloride content of the diet, as the previous reports (Selye).In relation to sod. chloride metablism, elevation of blood pressure due to overdosage of DCA was observed after the retention of NaCl, and preceded the nephrosclerosis in rats.The present experiment suggest that both DCA- and Salt-hypertension in rats are very similar in relation to developing through the retention of NaCl.
