肺循環に関する実験的並びに臨床的研究(第1報) : 石松子芽胞による実験的肺栓塞について

抄録

The author have induced pulmonary embolism by intravenous injection of 1% suspension of Lycopodium Spores in physiologic saline, and studied the hemodynamic changes in pulmonary circulation.1) 9 dogs were catheterized and measured the pulmonary arterial pressure, cardiac output and circulating bloodvolume before and after the embolism. Each of 6 dogs showed temporary arterial hypertension (maximal elevation in meanpressure was 4.1 times of control level) which have declined gradually and 38 minutcs (average) after embolism returned to the control pressure level. Hematocrit % have decreased and suggested the increase in blood plasma volume. Interpretation of T-1824 extrapolating curve have proved the mobilisation of depot blood.2) 9 dogs were repeatedly induced pulmonary embolism at intervalls of 7-10 days and catheterized before and after the first ambolism and 3-4 months later. Pulmonary arterial pressure have elevated slightly, but showed no correlation with time duration of embolism. Cardiac output have showed no or slight increase. Hematocrit %, red blood cell count and hemoglobin % have increased every time. All dogs showed increases in circulating blood volume, and hypertrophies of right ventricular walls.3) The facts that the pulmonary arterial hypertension is a temporary one, and that the absence of expected marked pulmonary arterial hypertension after repeated pulmonary embolism and the abscence of the decrease of pulmonary blood flow, suggests the vast reserve bypassing bloodways in the pulmonary vascular bed.