Abstract
The author performed the histologic and histochemical study of the adrenal cortex, determination of 17-ketosteroids in urine and caluclation of eosinophil count in blood ot investigate the relationship between experimental renal hypertension and adrenal cortex.Twenty adult dogs, 7.0-17.2 kg. weight, were uesd in this experiment, and hypertension produced by application of Goldblatt's clamp and by Page's cellophane perinephritis. They were divided into two groups. The first group consists of 12 dogs whose renal arteries were constricted by Goldblatt's clamp, and the second group consists of 8 dogs whose kidneys were wrapped by cellophane.In the course of experiment, the author performed the clinical examinations including the measurement of body weight, urinary volume, blood pressure, urinary 17-ketosteroids excretion and eosinophil count. After the animals were sacrificed, the author performed the histologic and histochemical examination of the adrenal cortex.The summary and conclusion of this study are as follows : Adrenal cortical changes occured in experimental renal hypertensive dogs due to application of Goldblatt's clamp and Page's cellophaneperinephritis were hypertrophy and hyperplasia of cells and an appearance of small ketosteroid droplets in zona glomerulosa of the adrenal cortex. These changes which are considered the sign of hyperfunction are almost proportional to the degree of the elevation of blood pressure and its duration. The sign of slight stress was observed in zona faciculata, but not marked in degree.There was no relations between urinary 17-ketosteroids excretion, eosinophil count and elevation of blood pressure.The changes of zona glomerulosa suggest that the hypersecretion of mineralocorticoids is concerned with the elevation of blood pressur in experimental renal hypertension.
