抄録
For the purpose of producing experimental hypertension, the ATP-ase fraction of the house-rar's kidney were administered in albino rats pretreated with DCA and salt or salt alone. The blood pressure of albino rats was elevated early after the beginning of administration of the ATP-ase fraction of the house-rat's kidney and this hypertension was irreversible even after stopping loading of salt. But in albino rats not treated with the ATP-ase fraction of kidney, while blood pressure was elevated slowly by virture of DCA, it came down after the cessation of loading of salt. The histological changes in albino rats treated with the ATP-ase fraction of kidney were degenerative and of various type in tubules, glomeruli and there were changes similar to necrotizing arteritis in arteries or arterioles in kidneys. But, in albino rats not treated with the ATP-ase fraction of kidney, only proliferation of endothelial cells of glomerular tufts were revealed.
