Abstract
There are many studies on the anticoagulant activity of dextran sulphate. In these studies, dextran sulphate is used to given for obstructive endoarteritis and thrombosis instead of heparin. However, recent studies with the low molecular and low S-content dextran sulphate (L. D. S.) approved that this kind of dextran sulphate has hypocholesteremic effect and enhances the lipolytic activity in serum of arteriosclerotic patients. K. YAMADA and co-workers found that the lipolytic activity due to this kind of sulphated polysuccharides was not parallel with the anticoagulant activity, and lipolytic activity was marked although the toxic effect due to this kind of sulphated polysucchride was less than that of heparin. They clinically used the low molecular weight and low S-content dextran sulphate for the disturbance of lipid metabolism in arteriosclerotic patients. According to S. TOMIZAWA, L. D. S. somewhat increased the contractile force in the rabbit heart prepared by the LANGENDORFF'S method. On the other hand blood pressure and respiration were not affected by the intravenous injection of 300mg per kg of L. D. S. However the mechanism of inotropic effect with L. D. S. was not obvious. The present study was designed to investigate the effect of L. D. S. on the coronary circulation and myocardial metabolism in experimental coronary insufficiency of dogs. In addition, clinical effect of L. D. S). on coronary heart diseases was also investigated.
