PHARMACOLOGICAL AND ELECTROPHYSIOLOGICAL ACTIONS OFPROSCILLARIDIN A THE MECHANISM OF BIGEMINAL RHYTHM INDUCED BY ITS TOXIC DOSAGE STUDIED BY THE CHANGE OF THE TRANSMEMBRANE ACTION POTENTIAL

Abstract

The mechanism of the bigeminal rhythm induced by the toxic dose of rapid acting unique cardiac glycoside; Proscillaridin A, was investigated by means of the intracellular microelectrode technique, upon the guinea pig ventricular fibers, and the clinical case record of bigeminal rhythm induced by its intoxication was also analysed. On the experimental finding, the bigeminal rhythm appeared when the repolarization phase 2 was decreased about 40%. Clinically, the plethysmographic finding may be the good parameter to judge the appropriate dosage of Proscillaridin A for its maintenance dose for every individual patient.