Abstract
Aureomycin forms chelate compounds with various metals, especially stable compounds with zirconium (IV), thorium (V), uranium (VI), aluminum, and magnesium. Cobalt and copper are also capable of forming the chelate compound with the antibiotic. A comparison of Aureomycin-metal chelates with 1-hydroxyanthraquinone chelates was made spectrophotometrically. The results of this experiment proved that the presence of the constituent functional groups, a peri-standing phenolic hydroxyl and carbonyl, in Aureomycin was important. The molar ratio of these complexes containing Zr, Th, or UO2 was determined by the continuous variation method of Job, and structural formulae of these complexes are suggested. It is believed that some of these chelates may offer a sensitive method for the chemical determination of Aureomycin and the allied compounds.
