イソヒノリン誘導体及び関連化合物の合成研究(第37報)Heterocyclic Acid Amide又はOximeに対するAllylbenzeneの反応による1-置換3-メチル-3,4-ジヒドロイソヒノリン誘導体の一新製法

抄録

Reactions of various heterocyclic aldoximes and acid amides with methyleugenol or safrole, by utilization of the new isoquinoline synthesis (Kametani procedure^1∼5)) gave the objective 1-substituted 3-methyl-6, 7-dimethoxy (or 6, 7-methylenedioxy)-3, 4-dihydro-isoquinoline, but the yield was generally less than 30%. The acid amides used were furan-and thiophene-2-carboxylic amides, and 4-methylthiazole-5-carboxylic amide. As the oxime, 2-furfuraldoxime was used, but the use of pyridine-carboxylic amide did not give the objective and unexpectedly cyanopyridine was obtained.