Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

細谷 健一

収録数 27,525本
(更新日 2020/02/24)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2018 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
68 巻 (2020) 2 号 p. 103-116
Total Syntheses of Lycopodium and Monoterpenoid Indole Alkaloids Based on Biosynthesis-Inspired Strategies もっと読む

The lessons from nature on biosynthesis of natural products might be beneficial for synthetic organic chemists to design unique synthetic approaches as well as to facilitate development of new synthetic methodologies. This review emphasized the merits of biosynthetic consideration in the chemical synthesis of complex natural products by describing the total syntheses of Lycopodium alkaloids and monoterpenoid indole alkaloids conducted in author’s laboratory.

68 巻 (2020) 2 号 p. 117-128
Synthetic Studies toward Dimeric Indole Alkaloids Based on Convergent Synthetic Strategy もっと読む

Various dimeric compounds comprising two structurally different indole units are ubiquitous in nature. These compounds are a pharmaceutically important class of natural products because several compounds in this class exhibit display greater potency and unique biological activities compared with the corresponding monomeric compounds. In particular, these dimeric compounds, which possess molecular weights that deviate from Lipinski’s rule, are anticipated to be useful as new drug candidates in the middle molecule drug discovery. This review presents an overview of efficient convergent syntheses of dimeric indole alkaloids, haplophytine, and T988s with the development of synthetic methodologies for linking the two indole units.

68 巻 (2020) 2 号 p. 129-132
Intracellular Delivery of Antisense DNA and siRNA with Amino Groups Masked with Disulfide Units もっと読む

A new efficient delivery method of oligonucleotide (ON) therapeutics is developed. Here, antisense ON and small interfering RNA (siRNA) with disulfide-masked amino units were designed and synthesized for efficient intracellular delivery. The developed method actually enabled direct delivery of these ON into the cytosol, where these ON showed the targeted silencing effects, with minimal cytotoxicity. The molecular design and evaluation reported in this article would be very informative for further developing efficient cytosol-delivery methods of therapeutic ONs for medicinal application.

68 巻 (2020) 2 号 p. 140-149
Quality Evaluation and Characterization of Fractions with Biological Activity from Ephedra Herb Extract and Ephedrine Alkaloids-Free Ephedra Herb Extract もっと読む

The structural characteristics of the fractions from Ephedra Herb extract (EHE) having c-Met kinase inhibitory effects and the fractions from ephedrine alkaloids-free Ephedra Herb extract (EFE) having analgesic and anti-influenza activities were characterized. The fractions comprised high-molecular-mass condensed tannins, which were mainly of the procyanidin B and partly procyanidin A types, including pyrogallol- and catechol-type flavan 3-ols as the extension and terminal units. HPLC and gel permeation chromatography (GPC) analyses estimated that the ratio of pyrogallol- and catechol-type was approximately 9:2 and the weight-average molecular weight based on polystyrene standard was >45,000. The authors propose GPC-based analysis as the quality method for evaluating of high-molecular-mass condensed tannin in EHE and EFE.

月間アクセス数ランキング 2020年01月