Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

細谷 健一

収録数 27,221本
(更新日 2018/08/21)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
2017 インパクトファクター
ジャーナル 査読 フリー HTML 早期公開
66 巻 (2018) 8 号 p. 773-778
Macrocyclic Compounds from Ansamycin Antibiotic Class as Inhibitors of PD1–PDL1 Protein–Protein Interaction もっと読む

Antibody therapies that bind to PD1 protein and inhibit its binding with PDL1 protein have shown unprecedented clinical success in activating innate immune system to treat cancer. Here, the authors investigated activity of several macrocyclic compounds in inhibiting PD1-PDL1 interaction, leading to identification of Rifabutin, an approved macrocyclic antibiotic, as top active compound with remarkable IC50 value of ~25 µM. Computational docking followed by molecular dynamics simulations revealed Rifabutin making key interactions with PD1, occupying and blocking majority of the area on PD1 protein where PDL1 is known to bind.

66 巻 (2018) 8 号 p. 794-804
Ultra Cryo-Milling with Liquid Nitrogen and Dry Ice Beads: Characterization of Dry Ice as Milling Beads for Application to Various Drug Compounds もっと読む

The authors developed a novel cryogenic milling technique in liquid nitrogen (LN2) using dry ice beads. The contamination issue related to fragments of eroded beads could be overcome due to their spontaneous removal. In this study, the transformation process from the pellets and the morphological change of dry ice beads during milling process in LN2 was monitored to assess their potential as milling media. The authors presented that dry ice could maintain its bead shape even under vigorous agitation in LN2. Further, they demonstrated that their milling performance was comparable to conventional technique using zirconia beads.

66 巻 (2018) 8 号 p. 805-809
Rapid Analysis of Cyclic Peptide Cyclosporine A by HPLC Using a Column Packed with Nonporous Particles もっと読む

The authors developed a rapid and efficient analytical technique for cyclosporine A using HPLC. Under optimized conditions, cyclosporine A was separated with high resolution from other cyclic peptides within 3 min, because the mass transfer resistance in the stationary phase was reduced by the use of the small, nonporous particle columns. The results indicate that cyclosporine A is structurally rigid and undergoes poor water solvation even at high temperature. In the context of the rapid development of cyclic peptides with similar physicochemical characteristics to cyclosporine A, the developed method is useful for the development of cyclic peptide therapeutics.

66 巻 (2018) 8 号 p. 810-817
Synthesis and Evaluation of Fuligocandin B Derivatives with Activity for Overcoming TRAIL Resistance もっと読む

Fuligocandin B isolated from the slime mold Fuligo candida induced apoptosis in TRAIL resistance cancer cells by increasing death receptor 5 (DR5) thorough binding to valosin-containing protein (VCP). Heterocyclic derivatives of fuligocandin B were synthesized and evaluated. Amine derivative designed based on docking simulation showed potent cytotoxicity against TRAIL resistance human gastric adenocarcinoma (AGS) cells. The figure represents picture of Fuligo candida, structure of 7’-amino fuligocandin B and image of increasing DR5 which goes to bind to TRAIL on the cell surface.

月間アクセス数ランキング 2018年07月
  • Chem. Pharm. Bull. Vol. 66 No. 5
    Current Topics: Natural Products Chemistry of Global Tropical and Subtropical Plants
  • Chem. Pharm. Bull. Vol. 66 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future

  • Chem. Pharm. Bull. Vol. 66 No. 1
    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides

  • Chem. Pharm. Bull. Vol. 66 No. 2
    Current Topics: Medicinal and Bioorganic Chemistry of Nucleosides and Nucleotides