Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約17000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

学術誌編集委員長
大槻 純男
熊本大学大学院生命科学研究部



もっと読む
収録数 27,826本
(更新日 2021/09/23)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1.645
2020 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
おすすめ記事
69 巻 (2021) 9 号 p. 819-831
Molecular Transformation Based on an Innovative Catalytic System もっと読む
編集者のコメント

Three hybrid catalysts have been designed based on the reaction mechanism of enzymes. These catalysts using non-covalent intermolecular interactions exhibit remarkable catalytic performance for the activation of α,β-unsaturated amides and carboxylic acids as well as the dynamic kinetic resolution of a racemic electrophile in an SN2-type reaction. These innovative catalytic systems allow the asymmetric synthesis of biologically important molecules such as atorvastatin, beraprost, sitagliptin, and avenaol.

69 巻 (2021) 9 号 p. 840-853
Environmental Risk Assessment of Active Human Pharmaceutical Ingredients in Urban Rivers in Japan もっと読む
編集者のコメント

In Japan, environmental risk assessments (ERA) for human pharmaceuticals in aquatic environments have barely begun. This paper reports the first study assessing the validity of ERA guidance issued by the Ministry of Health, Labour, and Welfare in 2016 for new medicinal products in the environment, using selected pharmaceuticals already on the market. The accuracy of predicted environmental concentrations was evaluated by measuring environmental concentrations in urban rivers. The results will be useful information applicable to ERA for new medicinal products, and development of future ERA standards in Japan.

69 巻 (2021) 9 号 p. 854-861
2-Thioxothiazolidin-4-one Analogs as Pan-PIM Kinase Inhibitors もっと読む
編集者のコメント

PIM kinases are attractive therapeutic targets for the treatment of multiple hematological malignancies. In search for novel PIM kinase inhibitors, the authors designed and synthesized a series of 5-benzylidene-2-thioxothiazolidin-4-one derivatives with various substitutions at the pyrazine rings. Several compounds exhibited subnanomolar to single-digit nanomolar potencies against all three PIM isoforms and showed anti-proliferative activities against human leukemic EOL-1 and MOLM-16 cell lines. The mechanism of action study of compound 17 clearly revealed that a pan-PIM inhibitor reduced phosphorylation of downstream substrates of PIM kinase such as BAD and 4EBP1 in a dose-dependent manner.

69 巻 (2021) 9 号 p. 877-885
Monitoring of Cocrystal Dissociation during the Wet Granulation Process in the Presence of Disintegrants by Using Low-Frequency Raman Spectroscopy もっと読む
編集者のコメント

Understanding the dissociation behavior of cocrystals is an essential task in particular during manufacturing process of the solid dosage forms containing cocrystals as active pharmaceutical ingredients (APIs). The authors have established the promising technique with low-frequency Raman spectroscopy as a monitoring tool for molecular state of APIs during wet granulation, which can detect the dissociation of cocrystals successively and the rate calculated from the spectra enabled to evaluate the stable cocrystal and the formulation with various disintegrants. These findings would help researchers to consider developable pharmaceuticals containing cocrystals.

69 巻 (2021) 9 号 p. 926-930
Construction of Acyclic All-Carbon Quaternary Stereocenter Based on Asymmetric Michael Addition of Chiral Amine もっと読む
編集者のコメント

An all-carbon quaternary stereocenter is found in many biologically and pharmaceutically active compounds, in spite of being one of the most difficult structures to construct in the field of synthetic organic chemistry. In the present study, we were able to construct all-carbon quaternary stereocenters in an acyclic system by utilizing a face-selective alkylation of enolate intermediates derived from an asymmetric Michael addition reaction of a chiral lithium amide with trisubstituted α,β-unsaturated esters. Moreover, the obtained Michael adduct was able to be converted to the β-amino ester having the all-carbon quaternary stereocenter by an oxidative deprotection.

すべてのおすすめ記事を見る
月間アクセス数ランキング 2021年08月
このページを共有する
過去の巻号を選ぶ
発行機関からのお知らせ
  • Announcement of Academic Journals’ Awards Chemical and Pharmaceutical Bulletin (CPB)
    https://cpb.pharm.or.jp/award/award.pdf
  • Chem. Pharm. Bull. Vol. 69 No. 1
    Current Topics: Pharmaceutical Research for Quality Evaluation and Characterization of Foods and Natural Products
  • Chem. Pharm. Bull. Vol. 68 No. 12
    Current Topics: New Era of Polyphenol Research
feedback
Top