Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

学術誌編集委員長
大槻 純男
熊本大学大学院生命科学研究部



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収録数 27,637本
(更新日 2020/09/20)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
1.416
2019 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
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68 巻 (2020) 9 号 p. 823-831
Nonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis もっと読む
編集者のコメント

The fungal meroterpenoid biosynthetic pathways exhibit an abundance of unusual chemistries and interesting enzyme reactions, including those of the multi-functional non-heme Fe(II)- and 2-oxoglutarate-dependent oxygenases that perform selective C–H activation/functionalization with unusual substrate promiscuity and catalytic versatility. Structure–function studies of these remarkable enzymes provide an excellent platform for the development of useful biocatalysts for synthetic biology to create novel molecules for drug discovery.

68 巻 (2020) 9 号 p. 832-836
Effect of Rubbing on the Distribution of Topically Applied Drugs into the Hair Follicles もっと読む
編集者のコメント

Rubbing actions are often conducted to apply topical formulations onto the skin. However, few studies have reported the reasons for the acceleration of drug permeation through skin after topical application with or without rubbing. In addition, no studies observed the effect of rubbing direction on the skin penetration-enhancement effects. In this paper, the authors investigated the effects of rubbing direction on the skin permeation and disposition of a model hydrophilic drug, caffeine. This paper provides useful information on the effect of rubbing action and rubbing direction on the skin permeation of topically applied drugs.

68 巻 (2020) 9 号 p. 864-867
Iriomoteolides-14a and 14b, New Cytotoxic 15-Membered Macrolides from Marine Dinoflagellate Amphidinium Species もっと読む
編集者のコメント

Marine dinoflagellates are well known as rich sources of biologically active compounds possessing unique chemical structures. This paper deals isolation and structure elucidation of two new cytotoxic 15-membered macrolides, iriomoteolodes-14a and 14b, from the marine dinoflagellate Amphidinium species collected off Iriomote Island, Okinawa. The structures including the absolute stereochemistry of eight stereocenters were determined on basis of spectroscopic data and chemical conversion method. These compounds are analogous to known macrolides, amphidinolides O and P, and the biosynthetic relationships for four compounds are also described.

68 巻 (2020) 9 号 p. 868-878
Collaborative Study to Validate Purity Determination by 1H Quantitative NMR Spectroscopy by Using Internal Calibration Methodology もっと読む
編集者のコメント

Quantitative nuclear magnetic resonance is a powerful tool in quantitative determination of the main component and impurities in a drug substance or a drug product because of its high accuracy, precision and efficiency. This method has the potential to establish metrological traceability easily and expected to be widely utilized for some compendial guidelines and official standards. In this study, the authors conducted an inter-laboratory comparison for qNMR methodology and confirmed that statistically qNMR has the competence to obtain the same quantification performance and accuracy as the conventional reliable methods.

68 巻 (2020) 9 号 p. 885-890
Labeling of Peroxide-Induced Oxidative Stress Hotspots by Hemin-Catalyzed Tyrosine Click もっと読む
編集者のコメント

Tyrosyl radical generation plays a major role in hemin/peroxide-induced oxidative stress. The authors developed a method for trapping tyrosyl radicals using a derivative of N-methyl luminol, a tyrosine labeling reagent. The derivative selectively forms a covalent bond with tyrosine residue (tyrosine click reaction) under single-electron oxidation conditions. This reaction labels oxidative stress hotspots not only at the protein level but also at the level of tyrosine residues undergoing oxidation. The cover picture depicts an image of tyrosine click reaction to aid in the visualization of hemin/peroxide-induced oxidative stress generated in blood vessels.

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  • Chem. Pharm. Bull. Vol. 68 No. 7
    Current Topics: Recent Progress in Drug Delivery System for Cancer Therapy
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    Current Topics: Drug Discovery: Recent Progress and the Future
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