Chemical and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約15,000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

大槻 純男
収録数 27,999本
(更新日 2022/10/04)
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
2021 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
70 巻 (2022) 10 号 p. 699-706
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton もっと読む

In recent years, research on antisense oligonucleotides and small interfering ribonucleic acids (siRNAs) has progressed rapidly. These oligonucleotide therapeutics have great potentials for the treatment of diseases that are difficult to approach with conventional drugs. To apply oligonucleotides as therapeutic agents, they are generally modified with artificial nucleic acids because natural DNA and RNA do not have sufficient duplex-forming ability or stability against nucleases. In this report, the authors designed and synthesized 6ʹ-C-spiro-thymidine with a fixed torsion angle γ as a novel material for oligonucleotide therapeutics.

70 巻 (2022) 10 号 p. 707-715
Hydrazide-Mediated Solubilizing Strategy for Poorly Soluble Peptides Using a Dialkoxybenzaldehyde Linker もっと読む

Chemically synthesized proteins are increasingly becoming a research tool for elucidating protein functions. Ligation technologies proceeding in aqueous conditions have accelerated chemical protein synthesis; however, poorly soluble characteristics of peptide intermediates often hamper the synthesis of proteins that researchers may need.
Kohei Sato and co-workers report late-stage solubilization of peptide hydrazides using hydrophilic tags possessing a dialkoxybenzaldehyde moiety. The inherent advantage of this approach is the superior property for easy attachment and detachment of the solubilizing tags, which is ideal for a broad substrate scope. Using this methodology, the researchers synthesized a ubiquitin dimer derivative successfully.

70 巻 (2022) 10 号 p. 735-739
Computation-Guided Total Synthesis of Vitisinol G もっと読む

The authors reported the computation-guided total synthesis of vitisinol G, a resveratrol dimer. Computational chemistry is useful in synthetic organic chemistry, as it can be used not only to analyze reaction mechanisms, but also to calculate biosynthetic pathways and to plan and evaluate strategies for total syntheses. They focused on the semi-pinacol rearrangement derived from calculations of the biosynthetic pathway of resveratrol dimers. DFT calculations were used to develop a synthetic strategy and the total synthesis of vitisinol G at 7.8% was achieved in 4 steps from resveratrol.

月間アクセス数ランキング (2022年09月)
  • Chem. Pharm. Bull. Vol. 70 No. 9
    Current Topics: Recent Advances in Molecular Space Chemistry
  • Chem. Pharm. Bull. Vol. 70 No. 8
    Current Topics: Recent Progress in Research on Membrane Dynamics and Membrane Transport
  • Chem. Pharm. Bull. Vol. 70 No. 5
    Current Topics: New Modalities and Strategies in Drug Delivery and Discovery
  • Announcement of Academic Journals’ Awards
    Chemical and Pharmaceutical Bulletin (CPB)
  • Chem. Pharm. Bull. Vol. 70 No. 1
    Current Topics: Liquid Chromatographic Techniques in Food Sciences