While the addition of cellulose
nanofiber (CNF) to tablet formulations during direct compression has attracted
increasing attention as a means for enhancing tablet strength and
disintegration, they are also known to increase the variation in tablet weight
and drug content. This study evaluated the effect of pulverized CNF on the
variation in tablet weight and drug content. The pulverized CNF reduced both
weight and drug content variation to a larger extent than untreated CNF.
Further, either CNF achieved sufficient tablet strength and short
disintegration time. Thus, the authors provided evidence that CNF is useful as
a multifunctional additive.
screening is a powerful technique for drug discovery today. In this work, a virtual
screening was performed to find SARS-Cov-2 PL protease inhibitors, utilizing a
chemical database consisting of approved and investigational drugs. A key issue
for successful virtual screening is the accuracy of computational predictions
for the binding pose and score of each compound to the target. The authors
applied their original software program, Chem. Pharm. Bull., 2017, 65, 461, for
calculating the score. Their approach identified five inhibitory compounds
against the PL protease. The inhibitory activities were evaluated by an
enzymatic assay with the FRET technique.
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular Carcinoma SMMC-7721 Cells
公開日: 2023/11/01 | 71 巻 11 号 p. 798-803
Na-Na He, Jian-An Wang, Di Huang, Xiao-Long Sun, Feng Ding, Long Zhao, Yu-Xin Zhang, Hong-Mei Li, Cheng-Zhu Wu