ピリドピラゾロン誘導体の合成研究(第1報)ピリド〔3,4-c〕ピラゾロン類の合成

抄録

1-Phenyl-2-methyl-3-β-aminoethyl-5-pyrazolone (VI) was prepared, which underwent Pictet-Spengler type of condensation, yielding 1-phenyl-2-methylpiperido[3, 4-c, ]-pyrazol-7-one (X). Veratroyl compound of (VI) was cyclized after Bischler-Napieralski-Perkin, giving 1-phenyl-2-methyl-3, 4-dihydropyrido[3, 4-c]pyrazol-7-one (IXb). Both (IXb) and (X) were dehydrogenated over palladium-carbon in boiling p-cymene, furnishing the corresponding pyrido derivatives (I) and (I'), respectively. Their pharmacological properties are now being examined.