Biochemical Studies on Pathogenic Fungi. VIII. The Effect of an Antibiotic, Trichomycin, on the Respiration and Phosphorus Metabolism of Trichophyton gypseum.
The action of Trichomycin on the respiration and phosphorus metabolism of Trichophyton gypseum was examined. This antibiotic stimulated the respiratory rate of this fungus in a range of 0.1∼100γ/cc., while it inhibited the rate markedly over 100γ/cc. The inhibitory action of Trichomycin upon the incorporation of phosphate into the cells from the surrounding medium was demonstrated with the aid of 32P-labeled phosphate. Such an effect appeared from 0.1γ/cc.
