Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Improved Synthesis of (2R, 3S, 4R)-3, 4-Dihydroxy-2-Hydroxymethyl-pyrrolidine Derivatives
NOBUO IKOTA, AKIRA HANAKI
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Keywords: selective methoxymethylation
JOURNAL FREE ACCESS

1988 Volume 36 Issue 3 Pages 1143-1146

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Abstract
An improved and facile synthesis of (2R, 3S, 4R)-2-hydroxymethyl-3, 4-dihydroxypyrrolidine derivatives (11 and 15), which are important intermendiates for the synthesis of (-)-swainsonine, from D-ribonolactone was developed.
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© The Pharmaceutical Society of Japan
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