Growth Hormone Therapy Does not Improve the Final Height of Girls with Short Stature not Caused by Growth Hormone Deficiency

抄録

Recently we reported that GH therapy might decrease the final height of boys with non-GH-deficient short stature. In this study we evaluated the effect of GH therapy on the final height of girls with non-GH-deficient short stature. Thirty-one girls with non-GH-deficient short stature who reached their final height were analyzed retrospectively. Patients in group A (n=11) were not treated with GH. Patients in group B (n=11) were treated with GH in doses of 0.5 IU (=0.17 mg)/kg per week. Patients in group C (n=9) were treated with a GH and cyproterone acetate combination in doses ranging from 50 to 100 mg/m²/day during puberty. GH or combination therapy with GH and cyproterone acetate did not improve the height SDS for BA during the therapy. The mean ± SD of the final height for groups A, B and C was 151.5 ± 5.3 cm, 150.2 ± 6.4 cm and 151.2 ± 4.1 cm, respectively. Neither GH therapy nor combination therapy with GH and cyproterone acetate affected the final height of girls with non-GH-deficient short stature. These results suggest that there are sexual differences in the effect of GH.