Originals
Physiological Function and Localization of a Short Isoform of the Corticotropin-Releasing Factor Receptor Subtype (CRF2α-tr) in the Rat Brain
2000 Volume 9 Issue 2 Pages 55-61
Details
2000 Volume 9 Issue 2 Pages 55-61
We recently isolated a cDNA encoding a short isoform of the corticotropin-releasing factor (CRF) receptor subtype, referred to as CRF2α-tr, from the rat amygdala. The present study utilized in situ hybridization histochemistry to localize the distribution of CRF2α-tr receptor mRNA in the rat brain. The results showed significant levels of hybridization in the lateral septum, central nucleus of the amygdaloid, cortico-amygdaloid nucleus, ventromedial hypothalamic nucleus (VMH), and frontal cortex. In the physiological study, antidepressive drugs increased the expression of CRF2α-tr mRNA and the total binding activity to CRF in the rat amygdala. These results suggest that CRF2α-tr may regulate the synthesis and secretion of CRF in the amygdala.
