The Response of Insulin-like Growth Factor Binding Protein-3 Complex to Growth Hormone

抄録

Biochemical markers of response to growth hormone (GH) have been determined by many groups for use as long term predictors of growth response. We have examined the changes in insulin-like growth factor binding protein (IGFBP) -3 by RIA in three groups of children (biochemical GH Deficiency (GHD, n=36), Chronic Renal Failure (CRF, n=22), Idiopathic Short Stature (ISS, n=101)) during six months treatment. Additionally, the alpha subunit of IGFBP-3 (ALS) was measured in the last group. Ten GHD children showed during the first 24 hours a mean IGFBP-3 increase of 37% and this change strongly related to the change in the sum of IGF₁ + IGF₁₁ (r=0.882). The change at three and six months for the GHD group was variable and did not relate to an individual's growth response. IGFBP-3 was high in CRF group at baseline and did not rise during therapy. Both mean IGFBP-3 and ALS showed a dose dependent rise when two doses of GH were given for six months in ISS group but this change was less than seen with mean IGF₁ and could not be used to confidently predict subsequent growth response. These studies confirm the GH dependence of IGFBP-3 but its routine measurement for prediction of future growth is not indicated.