抄録
Behçet’s disease (BD) is a systemic disease presenting oral and genital ulceration, other skin lesions, uveitis and manifestations affecting the blood vessels. Among those, entero-Behçet’s disease is characterized by bowel inflammation with round and oval ulcers associated with gastro-entero-intestinal symptoms. BD is frequent in the Middle and Far East but is rare in the Europe and Western world, suggesting the contribution of a racial or genetic factor. Indeed, Human leukocyte antigen (HLA)-B 51 is a well-known genetic factor associated with BD.
We report a case of a 25-year-old man with a 3-year history of entero-Behçet’s disease having surgical treatment three times after the disease onset. This patient was introduced to our hospital presenting with melena and lower abdominal pain, while he has been treated with prednisone, colchicine, mesalazine and infliximab for 3 years. Laboratory test results on admission were as follows; WBC 14000/ml, Hb 9.8 g/ml, CRP 0.55 mg/dl, AST 30 U/ml, ALT 75 U/ml, total protein 5.2 g/dl and albumin 2.6 g/dl. After entering our hospital, despite an additional treatment of neutrophil apheresis (G-CAP) for 5 times, he underwent surgery twice owing to massive hematochezia and sature-failure due to long-term steroid usage.
The efficacy and indication of steroid, biologics, neutrophil apheresis and surgical therapy for entero-Behçet’s disease were discussed.
