Two autopsy cases of Sjögren syndrome with rare malignant lymphoma lesions

Abstract

    We report two autopsy cases of Sjögren syndrome (SjS) with rare malignant lymphoma lesions. The first patient was an 83-year-old woman with rheumatoid arthritis and SjS. She had the chief complaint of edema in both lower limbs. Computed tomography (CT) and magnetic resonance imaging revealed a mass lesion in her uterus. The other SjS patient was an 83-year-old man with the chief complaint of fever. His CT showed masses in both adrenal glands. Owing to their poor general condition, we could not perform biopsy for diagnosis of these tumors while they lived. Autopsies revealed the presence of diffuse large B-cell lymphoma in both patients. To our knowledge, this is the first report of rare lymphoma lesions in the uterus and in both adrenal glands in patients with SjS. Malignant lymphoma occurring in unusual organs should be considered in differential diagnosis of tumors in patients with SjS.