抄録
Group3 late embryogenesis abundant (G3LEA) proteins have the ability to protect proteins/enzymes and liposome from desiccation stress. They commonly have characteristic 11-mer repeat motif. In our previous studies, we synthesized short model peptides with two or four tandem repeats of such an 11-mer motif and demonstrated that they exhibit the protective activity similar to those of the native G3LEA proteins. However, the underlying mechanism for such protective functions remains unclear. In this study, to elucidate the mechanism at atomic level, we perform coarse-grained molecular dynamics simulations for a lysozyme-G3LEA peptide mixed system. It is shown that the G3LEA peptide molecules enter the interfacial space between two lysozyme molecules in the dry state and thus act as a barrier to avoid the direct contact between them.
