Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
REVIEW
Autophagosome Formation in Mammalian Cells
Noboru MizushimaYoshinori OhsumiTamotsu Yoshimori
Author information
JOURNALS FREE ACCESS

2002 Volume 27 Issue 6 Pages 421-429

Details
Abstract

Macroautophagy is an intracellular degradation system for the majority of proteins and some organelles. The molecular mechanism of autophagy has been extensively studied using the yeast, Saccharomyces cerevisiae, during these past 10 years. These studies suggested that the molecular machinery of autophagosome formation is well conserved from yeast to higher eukaryotes. Identification and characterization of the mammalian counterparts of the yeast autophagy proteins has facilitated our understanding of mammalian autophagy, particularly of autophagosome formation. These findings are now being applied to studies on the physiological roles of autophagy in mammals.

Information related to the author
© 2002 by Japan Society for Cell Biology
Previous article Next article
feedback
Top