Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
REVIEW
Roles of MAPKKK ASK1 in Stress-Induced Cell Death
Kohsuke TakedaAtsushi MatsuzawaHideki NishitohHidenori Ichijo
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Keywords: MAPKKK, ASK1, JNK, p38, apoptosis
JOURNALS FREE ACCESS

2003 Volume 28 Issue 1 Pages 23-29

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Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein (MAP) kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 MAP kinase signaling cascades. Recent findings from analyses of ASK1-deficient mice have revealed that ASK1 is required for apoptosis induced by oxidative stress, TNF and endoplasmic reticulum (ER) stress. In addition, several lines of evidence have suggested that ASK1 has diverse functions in the decision of cell fate beyond its pro-apoptotic activity. Thus, ASK1 appears to be a pivotal component not only in stress-induced cell death but also in a broad range of biological activities in order for cells to adapt to or oppose various stresses.

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© 2003 by Japan Society for Cell Biology
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