Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity
Miki Yamamoto-HinoSatoshi Goto
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2016 Volume 41 Issue 1 Pages 55-60

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Abstract

The Toll pathway regulates innate immunity in insects and vertebrates. The Drosophila Toll receptor is activated by a processed form of a ligand, Spätzle. Spätzle-processing enzyme (SPE) is the only enzyme identified to date that functions in converting Spätzle to an active form during the immune response. In the present study, Toll activation induced by immune challenge was almost suppressed in spätzle mutant larvae and adults, whereas it was present in SPE mutant larvae challenged with Micrococcus luteus and adults challenged with Bacillus subtilis. Our data suggest that an unidentified protease besides SPE processes Spätzle under conditions of microbial challenge.

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© 2016 by Japan Society for Cell Biology
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