Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
Glycosphingolipid GM2 Induces Invasiveness in Irradiation-tolerant Lung Cancer Cells
Seiichiro IshiharaKei AokiTakeomi MizutaniMaho AmanoShin-Ichiro NishimuraHisashi Haga
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2018 Volume 43 Issue 2 Pages 177-185

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Abstract

Glycans, including glycosphingolipids, are broadly expressed in plasma membranes and play important roles in cell-cell interactions. Recently, it has been revealed that glycans participate in the regulation of malignant phenotypes of cancer cells, e.g. growth and invasion. However, their roles in irradiation-tolerant cancer cells have not yet been elucidated. In this study, we show that specific glycosphingolipids are highly expressed in invasive, irradiation-tolerant lung cancer cells. Particularly, the glycosphingolipid GM2 contributes to the development of an invasive phenotype in these lung cancer cells. Our results suggest that glycosphingolipids, including GM2, are implicated in the regulation of invasiveness in irradiation-tolerant lung cancer cells and may therefore serve as potential therapeutic targets for lung cancers following radiotherapy.

Key words: glycosphingolipids, GM2, invasion, lung cancer cells, radiotherapy

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© 2018 The Author(s) CC-BY 4.0 (Submission before October 2016: Copyright © Japan Society for Cell Biology)
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