Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles
Yusuke TakanashiTomoaki KahyoSae KamamotoHengsen ZhangBin ChenYashuang PingKiyomichi MizunoAkikazu KawaseKei KoizumiMasanori SatouKazuhito FunaiNorihiko ShiiyaMitsutoshi Setou
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2022 Volume 47 Issue 1 Pages 1-18


Ubiquitin-like 3 (UBL3) is a well-conserved ubiquitin-like protein (UBL) in eukaryotes and regulates the ubiquitin cascade, but the significant roles of UBL3 in cellular processes remained unknown. Recently, UBL3 was elucidated to be a post-translational modification factor that promotes protein sorting to small extracellular vesicles (sEVs). Proteins sorted into sEVs have been studied as etiologies of sEV-related diseases. Also, there have been attempts to construct drug delivery systems (DDSs) by loading proteins into sEVs. In this review, we introduce the new concept that UBL3 has a critical role in the protein-sorting system and compare structure conservation between UBL3 and other UBLs from an evolutionary perspective. We conclude with future perspectives for the utility of UBL3 in sEV-related diseases and DDS.

Key words: UBL3, small extracellular vesicles, protein sorting, ubiquitin-like protein, post-translational modification

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© 2022 The Author(s) CC-BY 4.0 (Submission before October 2016: Copyright © Japan Society for Cell Biology)

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