Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Changes in Intracellular K+ and Na+ Ion Concentrations During Cell Growth and Differentiation
Kuniaki TakagiYoshie OkabeKeigi YoshimuraYasuo Ichikawa
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1986 Volume 11 Issue 3 Pages 235-243


ABSTRACT We compared intracellular K+ and Na+ ion concentrations during cell growth and differentiation of a mouse myeloid leukemia M1 cell line. Cells undergoing mitosis had higher K+ concentrations than quiescent cells. Treatment with a K+ channel blocker and furosemide enhanced cell growth and produced a slight increase in the intracellular K+ concentration. Treatment with reagents that reduced the intracellular K+ concentation stopped cell growth. Induction of differentiation in this cell line produced a decrease in the K+ concentration, which always was accompanied by an increase in the Na+ concentration. Treatment with ouabain, which decreased the intracellular K+ concentration, did not, however, induce differentiation in the Ml cell line. The data suggest that cell growth and differentiation in the M1 cells are accompanied by changes in the intracellular K+ and Na+ concen-trations but that the changes in the contents of these monovalent cations do not necessarily induce differentiation in this cell line.

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