Abstract
Some evidences have been found that virulency in paramyxoviruses depends on the sensitivity of the cleavage recognition site ofthe F glycoprotein to serine type proteases. In this report, the interactionenergies between the active site of trypsin and the cleavage recognition sites inparamyxoviruses are calculated. Results show that van der Waals energy andelectrostatic energy contribute to the sensitivity. The virulencies of some myxo-and retro-viruses are then predicted on the basis of the two calculated interac-tion energy values.
