Abstract
A new endothelial cell growth factor (f-ECGF) was partially purified from the cultured medium of human fibroblast cells of embryonic lungs. The partially purified f-ECGF induced neovascularization in rabbit cor-nea. It showed a selective growth stimulatory activity on the endothelial cells in vitro, whereas acidic-and basic-fibroblast growth factors (a-and b-FGFs) show-ed a broad spectrum of growth stimulation among tissues or cells. f-ECGF did not compete with the binding of a-FGF to the cell surface receptor in HEP-G2 hepatoblastoma cell lines. These results indicated that f-ECGF is a new en-dothelial cell growth factor distinct from a-and b-FGFs which are known to be potent endothelial cell growth factors.
