Difference in Laminin Expression Between High and LowMetastatic Cell Clones Derived from Murine Lewis Lung Carcinoma

Koh Nanimi; Ken Satoh; Mamoru Isemura; Toshihiko Sakai; Tatsuya Abe; Toshiaki Kikuchi; Satoshi Sindoh; Masakichi Motomiya; Kayoko Oguri; Minoru Okayama

doi:10.1247/csf.18.183

Koh Nanimi, Ken Satoh, Mamoru Isemura, Toshihiko Sakai, Tatsuya Abe, Toshiaki Kikuchi, Satoshi Sindoh, Masakichi Motomiya, Kayoko Oguri, Minoru Okayama

Author information

Koh Nanimi
Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University
Ken Satoh
Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University
Mamoru Isemura
School of Food and Nutritional Sciences, University of Shizuoka
Toshihiko Sakai
Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University
Tatsuya Abe
Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University
Toshiaki Kikuchi
Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University
Satoshi Sindoh
Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University
Masakichi Motomiya
Department of Respiratory Medicine, The Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University
Kayoko Oguri
Clinical Research Institute, National Nagoya Hospital
Minoru Okayama
Clinical Research Institute, National Nagoya Hospital

Keywords: Laminin, Laminin Receptor, Lewis Lung Carcinoma, Metastasis

JOURNAL FREE ACCESS

1993 Volume 18 Issue 3 Pages 183-187

DOI https://doi.org/10.1247/csf.18.183

Details

Abstract

We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings showthe possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.

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