Cell Structure and Function
Online ISSN : 1347-3700
Print ISSN : 0386-7196
ISSN-L : 0386-7196
Difference in Laminin Expression Between High and LowMetastatic Cell Clones Derived from Murine Lewis Lung Carcinoma
Koh NanimiKen SatohMamoru IsemuraToshihiko SakaiTatsuya AbeToshiaki KikuchiSatoshi SindohMasakichi MotomiyaKayoko OguriMinoru Okayama
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1993 Volume 18 Issue 3 Pages 183-187


We investigated the expression of laminin in two cell lines with different metastatic potentials established from murine Lewis lung carcinoma. Immunostaining of the cells with anti-laminin antibody and Northern blot analysis of laminin mRNA demonstrated that the high metastatic clone expressed less laminin than the low metastatic one. In contrast, expressions of 67 kDa-laminin receptor were at similar levels between these two lines. These findings showthe possibility that endogenous laminin may contribute to the difference in metastatic properties in the murine Lewis lung carcinoma cell lines examined.

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