2005 年 70 巻 3 号 p. 303-308
The clastogenic effect of the Austroplenckia populnea bark wood extract was tested in vivo on bone marrow cells of Wistar rats by evaluating the induction of chromosome aberrations and micronuclei induction on polychromatic erythrocytes. The extract was administered by gavage at doses of 300, 600 and 900 mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment. A. populnea bark wood extract induced a dose related significant increase in the mean of chromosomal aberrations for the two higher doses and also a dose related significant increase in the mean of the micronucleated polychromatic erythrocytes to the three tested doses. Our findings suggest that A. populnea bark wood extract is clastogenic in the bone marrow cells of Wistar rats.
