Abstract
"Cultured skin substitutes" have been developed, and they have already been in practical use in order to widely improve severe burns in recent years due to dramatic advances of tissue engineering. Secondary infection by some bacteria, however, is a possible problem when implanting such skin substitutes. Although protecting the wound skin using skin substitutes is a primary treatment, drug therapies with antibiotic ointments are usually followed. A greater therapeutic effect may be obtained by direct application of the cultured skin substitute containing an antimicrobial substance as a drug formulation on the wound skin. This review introduces the current investigation of dermal patches consisted of cultured skin as a novel DDS for sever skin defects such as severe burns or decubitus.
