Abstract
Polysarcosine（PSar） is a promising polymeric material for drug delivery systems（DDS）, characterized by its non-ionic nature, high hydrophilicity, and low immunogenicity. This review introduces the chemical structure, biocompatibility, synthesis methods, and applications of PSar, with a particular focus on the authors’ studies using lactosomes and liposomes to evaluate immune responses. Through these studies, it was demonstrated that structural parameters—such as chain length, surface density, and linkage—significantly influence the immunogenicity of PSar-modified nanocarriers. These findings provide a rational basis for the molecular design of PSar-based DDS with controlled immune responses and enhanced stealth properties. PSar has thus been shown to offer not only functional versatility but also the structural tunability necessary for next-generation nanomedicine.
