抄録
We evaluated the tissue distribution and antitumor effects of freeze-dried, liposome-entrapped carboplatin (lipo-CBDCA) injected via the portal vein (ipv.) to rats bearing AH 130 tumors. The liposomes consisted of egg lecithin and cholesterol. The serum concentration of platinum (Pt) was higher following the lipo-CBDCA i.p.v than following the free CBDCA given i.p.v or i.v, at 3 and 6 hours after administration. The liver concentration of Pt was increased after administration of the liposome preparation vs. free drug. The in vivo antitumor effect of lipo-CBDCA was evaluated in rats inoculated with AH 130 tumor. Administration of free CBDCA i.p.v prolonged the survival of tumor-bearing rats. Survival was further prolonged by lipo-CBDCA vs. the control group or the group receiving free CBDCA. All rats treated with lipo-CBDCA i.p.v survived, and their liver metastases were disappeared completely. No serious effects were observed in studies of liver and kidney function. These results indicate that administration of lipo-CBDCA via the portal vein may be more effective in treating liver metastases than free CBDCA, and appeared non toxic to rats.
