抄録
It was found that the stratum corneum was completely disrupted to intact individual corneocytes only by immersion in an aqueous solution of lauryldimethylamine oxide (LDMAO) /d-limonene mixture. The enhancing effect of binary system containing LDMAO and d-limonene on the skin permeation of antipyrine, a water-soluble model drug, was evaluated by in vitro permeation technique using hairless rat abdominal skin mounted in Franz type diffusion cells. The skin permeability of antipyrine in LDMAO/d-limonene binary system was higher than that in water without enhancer and that in each one of the binary system. It was found that when d-limonene was added at a concentration of 10 mM in 20 mM LDMAO aqueous solution, the additive effect of d-limonene reduced the lag time period of antipyrine permeation. The effect of alkyl chain length of a series of alkyldimethylamine oxides on the skin permeation of antipyrine was evaluated. The maximum effect was observed in the case of LDMAO, a chain length of twelve carbons. We have found LDMAO/d-limonene binary system to be usefull as penetration enhancer.
