抄録
Techniques and therapeutic effects for liver metastases of hepatic arterial infusion chemotherapy are introduced. The arterial redistribution by steel coils or liquid embolic material to gain the entire liver drug distribution and to prevent extra-hepatic drug distribution is very important for the long term repeated hepatic arterial infusion chemotherapy without complications, And the techniques for percutaneous hepatic arterial catheter placement is established and its invasion is very limited compared with that by laparotomy. In our phase II study, the response rate, median survival and prevention rate of death were 75%, 22mo, 62% in colorectal cancer (n=32), 72%, 17mo, 72% in gastric cancer (n=40) and 81%, 12mo, 70% in breast cancer (n=56), respectively. Thus, hepatic arterial infusion chemotherapy is highly active and has much potential for preventing death due to liver metastases without major reduction of pts' QOL. However, the role of this therapy on the therapeutic strategies for liver metastases is not established, because the impact on survival of this therapy compared with systemic chemotherapy is uncertain.
