リポ製剤からの薬物放出挙動に関する解析法の比較

抄録

Lipo-PGE₁ is a drug delivery system useful for administration of small quantities of drugs. Lipo-PGE₁ efficiently delivers prostaglandin E₁ (PGE₁) to the sites of lesions, and has potent peripheral vascular dilatative and anti-platelet effects. It is very important that drugs are retained in the lipidic particles. Some studies on the retentivity of drugs in lipidic particles have been reported but ways of thinking about and experimental methods are not standardized. Therefore, we compared methods of separation of aqueous phase in Lipo-PGE₁ using a membrane filter, an ultrafilter or a dialysis tube. The dialysis method was found to be most suitable if a kinetic analysis was performed. For this analysis, diffusion theory and successive first-order reactions were used. We found that the predictions of the diffusion method agreed with the experimental values and expressed the equilibrium state. Retentivity of PGE₁ in lipidic particles was analyzed using the most suitable method. Lipo-PGE₁ exhibited high retentivity of PGE₁ in the lipidic particles and preserved its faculty as drug carrier.