微粒子製剤設計とDDS

高分子ナノスフェアを用いたペプチド経粘膜投与製剤の設計

抄録

Firstly the superior properties of polymeric nanoparticulate systems to other systems for mucosal peptide delivery as an alternative injection are over looked. Then novel mucosal peptide delivery systems developed by using those particulate systems are reviewed with introducing our systems. The oral mucoadhesive lactide glycolide copolymer (PLGA) nanospheres improved the absorption of calcitonin due to prolonging the retention time and the drug release at the absorption site in rat. Powdered pulmonary systems with PLGA nanospheres and hydroxypropylmethylcellulose phthalate (HPMCP) nanospheres for prolonged and rapid acting peptide delivery systems were successfully developed by us, respectively.