Abstract
This paper describes a study about tissue distri-bution of localy injected a new dosage from(ACR-CH)of adarubicin(ACR) The new doseage form(ACR-CH), developed in order to distribute a greater amount of aclarubicin to regional lympy nodes, comprises 20 mg of polyvinylpyrolidone and 50 mg of small activated carbon particles adsorbing 5 mg/ml of ACR in saline. The particle size of activated carbon in the form of suspension is 167 μm on average. Aclar-ubicin at 5 mg/kg was injected subcutaneously into right forefoot-pad of rat in the form of ACR-CH or the ACR aqueous solution. The concentration of ACR in the tissues was measured upto 7 days after administration with high pressue liquid chromato-graphy method. Statistically, ACR concentration in the axillary lymph nodes of rats given ACR-CH was higher than 10 μg/g for 24 hours after adminis-tration and the value was significantly higher than that of rats given ACR aqueous solution. ACR concentration in blood and the other tissues(the heart, the lung, the spleen, the kidney)of rats given ACR-CH were statistically significantly lower than those of the rats given ACR aqueous solution. These results leads us to think that ACR-CH distributes a large amount of ACR into the regional lymph nodes and small amounts to the tissues of whole body.
