抄録
Cellular immune parameters in peripheral blood were monitored for 4 weeks after chemoemboliza-tion with microencapsulated anticancer drugs, in order to investigate possible immune consequences after the therapy. The number and median age of the subjects were 30 and 63 (48-79), respectively. The subjects all had urological malignancies including 7 renal cell car-cinomas, 3 renal pelvic carcinomas, 13 bladder carcinomas and 7 prostatic carcinomas. Natural killer (NK) cell activity and CD4/8 ratio were augmented in 60% and 77% of the cases after chemoembolization respectively. Mature NK cell population (Leu7-CD16+) in these cases also showed a trend of contineous increase for more than 4 weeks. On the other hand, a small number of the patients showed an augmentation of CD3+ cells, I a-1+ cells or response to phytohemmagulutinin. These findings suggest that enhanced natural killer cell activity could be anticipated in more than a half of cases after chemoembolization.
