抄録
In order to speculate the disposition of cetylmannoside-modified liposomes (Man-MLV) in human, interactions between Man-MLV and plasma were investigated in this study. Man-MLV was rapidly destabilized in human fresh plasma, as same as in rat fresh plasma. On the other hand, liposomes without the surface modification of cetylannoside(PC-MLV)was not destabilized in human fresh plasma, altough PC-MLV was destabilized in rat fresh plasma. Furthermore, the instability of Man-MLV in human fresh plasma was induced by the activation of the classical pathway of complement, but that in rat fresh plasma was induced by the activation of the alternative complement pathway. These results suggested that there was the possibility of species differences on dispositions of liposomes in vivo. The present study is considered to be useful for clinical application of liposomes as drug carrier.
