抄録
Lactose carrying polystyrene (PVLA) had been shown to be a good matrix for hepatocyte culture due to specific interaction between the galactose residue and asialoglycoprotein receptors on hepatocyte. In this study, we investigated the possible applicability of this specific interaction and the ability of PVLA to form super molecular structures, which could serve as a drug carrier, in targeted delivery of drugs. Spectrophotometric observations indicated that the super molecular structure, resulting from the amphiphilic property of PVLA interacted strongly with ANS (8-anilino-1-naphthalenesulfonic acid), our hydrophilic drug models, and DPH (1, 6-diphenyl-1, 3, 5-hexatriene) or NBD (7-benyyl-4-nitrobenz-2-oxa-1, 3-diazole), our hydrophobic drug models, to form inclusion complexes of drugs and PVLA. When hepatocytes were incubated with the PVLA-NBD inclusion complex, high amount of NBD was transferred into hepatocytes. These results suggest that PVLA could be used as hepatocyte targeting drug carrier.
