Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Original Articles
Prophylactic effect of Withania somnifera on inflammation in a non-autoimmune prone murine model of lupus
Ujla MinhasRanjana MinzArchana Bhatnagar
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2011 Volume 5 Issue 4 Pages 195-201

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Abstract

The immunosuppressive properties of an aqueous suspension of Withania somnifera (WS) root powder were investigated in a pristane induced female Balb/c model of a systemic lupus erythematosus (SLE) like disease. The course of disease is initiated by peritoneal inflammation caused by pristane which results in development of SLE like symptoms, i.e. autoantibody production, proteinuria, and nephritis within a period of five to six months. The model of SLE was established by injecting 0.5 mL of pristane intraperitoneally into female Balb/c mice (12-18 weeks old). WS root powder (500 mg and 1,000 mg per kg body weight) was administered orally from one month prior to disease induction and for the following 6 months. Parameters of inflammation like nitric oxide (NO), Interleukin 6 and tumour necrosis factor-α and reactive oxygen species (ROS) in serum and/or ascitic fluid were measured. Prophylactic administration of WS root powder (500 mg and 1,000 mg per kg body weight) potently inhibits the pro-inflammatory cytokines, NO, and ROS in the ascitic fluid as well as in serum. Therefore, our results indicate a preventive effect of WS root powder on the mouse model of lupus.

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© 2011 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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