Drug Discoveries & Therapeutics
Online ISSN : 1881-784X
Print ISSN : 1881-7831
ISSN-L : 1881-7831
Brief Report
16,17-dihydroxycyclooctatin, a new diterpene from Streptomyces sp.LZ35
Guishi ZhaoShanren LiYuanyuan WangHuilin HaoYuemao ShenChunhua Lu
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Supplementary material

2013 Volume 7 Issue 5 Pages 185-188

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Abstract

Genome sequence analysis of Streptomyces sp. LZ35 has revealed a large number of secondary metabolite pathways, including a complete gene cluster for the biosynthesis of cyclooctatin. This cluster contains four genes, cotB1–4, located in a 5-kb region. Optimization of fermentation medium for LZ35Δheng (SR107) led to the identification of cyclooctatin (1) and 16,17-dihydroxycyclooctatin (2), a new diterpene. The structures of these substances were elucidated on the basis of 1D-, 2D-NMR, and HRESIMS data. Cytotoxicity against MDA-MB-231 and A549 cell lines was also evaluated. Results demonstrated that gene cluster and pathway analysis are key to guided isolation of new natural products.

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© 2013 International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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