口腔および上顎洞原発の扁平上皮癌患者に対するNedaplatin併用放射線治療によるTh1/Th2およびTc1/Tc2バランスの変化

抄録

This study investigated immunological changes in Th1/Th2 and Tc1/Tc2 balances due to Nedaplatin-assisted radiation therapy in patients with oral squamous cell carcinoma.
The subjects were 25 patients with oral squamous cell carcinoma (SCC group) and were compared with 24 cancer-free patients (control group) whose ages were almost the same as those in the SCC group. In the SCC group, 20 patients, who were treated with Nedaplatin-assisted radiation therapy, were investigated before and after treatment. The number of lymphocytes, CD4⁺ T cells and CD8⁺ T cells were measured. Furthermore, the percentage of Th1 cells, Th2 cells, Tc1 cells and Tc2 cells were measured by the intracellular cytokine method.
The following results were obtained:
1. In the comparison between control group and SCC group, the number of lymphocytes, CD4⁺ T cells and CD8⁺ T cells, and Th1/Th2 ratio and Tc1/Tc2 ratio did not change significantly. However, the percentage of Th1 cells and Th2 cells increased significantly in the SCC group, although the percentage of Tc1 cells and Tc2 cells did not change significantly.
2. The number of lymphocytes, CD4⁺ T cells and CD8⁺ T cells decreased significantly, and the percentage of Th1 cells, Th2 cells, Tc1 cells and Tc2 cells, and Th1/Th2 ratio and Tc1/Tc2 ratio did not change significantly after Nedaplatin-assisted radiation therapy.
These results indicated that the Nedaplatin-assisted radiation therapy has immunological merit, because it did not influence either the Th1/Th2 balance or the Tc1/Tc2 balance.