DMBA誘発舌癌における放射線及びセファランチンのポリアミン変動に対する影響

抄録

Polyamine content as a marker for malignant tumor growth was studied by 3Gy irradiation with or without combinations of cephalanthin in the DMBA induced tongue cancer of golden hamster. The amount of some polyamines was higher in the tumor site compared to the normal site, i. e., a considerable amount of cadaverine (Cd) was detected in the tumor site, while not in the normal site. A significant increase in the amount of putrescine (Pu) in the tumor site was also shown compared to the normal site. The amount of histamine (Hi), spermidine (Sd), spermine (Sm) showed no significant difference between the tumor and normal site. No significant change in the amounts of polyamines was observed by the treatment of cephalanthin alone and significant decrease in Cd and Sd was observed by a 3Gy local irradiation. This change was scarcely shown in the normal site. The combined effect of 3Gy irradiation and cephalantin resulted in a small but not significant decrease in the amount of polyamines.