Functional Analysis of the Strarum Corneum in Newborns

Abstract

The stratum corneum function in full-term newborns was evaluated at days 3, 14, and 28 after birth using non-invasive instrumental measurements. The hydrosity state and water holding capacity were significantly lower than those in healthy adult controls at days 3 and 14 and matured in one month after birth. The transepidermal water loss was as low as that in adults during the neonatal period. The results suggest that newborn skin is dry and that water holding capacity is immature at least for two weeks after birth, while the skin barrier function develops well. Gentle, moisturing techniques should be employed in bady bathing in order to protect the immature straum corneum. The three functional properties were not significantly different between newborns with and without a family history of allergic diseases, including atopic dermatitis.