The usefulness of moisturizers (heparinoid preparation) for maintenance of remission in atopic dermatitis (AD) was studied in a randomized controlled trial (RCT). A total of 65 patients who applied a heparinoid preparation twice daily for two weeks to their dry skin after topical steroid treatment were randomly assigned to either the heparinoid preparation continuous application group or the untreated control group. All patients were followed up for six weeks at most. Inflammation relapsed in 12.5% of the heparinoid preparation group and 39.4% of the control group, indicating significant inhibition of inflammation relapse in the heparinoid preparation group (χ2=6.0841, p=0.0136). A significant difference was observed in the period of no inflammation between the two groups (log-rank test, p=0.0117), suggesting that continuous application of the heparinoid preparation extends the period to inflammation relapse. This study demonstrates the usefulness of moisturizers for sustained remission of AD.
The stratum corneum function in full-term newborns was evaluated at days 3, 14, and 28 after birth using non-invasive instrumental measurements. The hydrosity state and water holding capacity were significantly lower than those in healthy adult controls at days 3 and 14 and matured in one month after birth. The transepidermal water loss was as low as that in adults during the neonatal period. The results suggest that newborn skin is dry and that water holding capacity is immature at least for two weeks after birth, while the skin barrier function develops well. Gentle, moisturing techniques should be employed in bady bathing in order to protect the immature straum corneum. The three functional properties were not significantly different between newborns with and without a family history of allergic diseases, including atopic dermatitis.
We report two cases of chronic expanding hematoma. Case 1 was a 72-year-old woman who presented with a subcutaneous tumor on her right clavicular region. The tumor developed on the site of a past operation that was performed 14 years previously. Case 2 was an 80-year-old man presenting with an easily bleeding subcutaneous tumor on his left scapular region. A trauma had triggered the occurrence of the tumor on the site of an operation performed 43 years previously. On first examination, our tentative diagnoses were malignant tumors of the soft tissue in both patients based upon their medical histories and clinical appearances. However, histological specimens from the excised tumors disclosed that they were chronic expanding hematoma without any indication of a malignant tumor. The similarities between soft tissue tumors and chronic expanding hematoma should be kept in mind.
We report a case of lupus erythmetosus tumidus and evaluate a set of diagnostic criteria based upon the clinical, histopathological, and immunoserological findings. The patient was a 41-year-old female, who had undergone treatment from the age of 17 for an undetermined collagen disease. She presented with tender, erythematous, edematous, indurated plaques with a reticular pattern and papular lesions on the face, chest, back, and upper extremities. The skin lesions had a smooth surface without any epidermal changes such as atrophy, scaling, follicular plugging, or scars. The titer of antinuclear antibody (ANA) was 1 : 320. Histopathologically, there was a slight infiltration of inflammatory cells at the dermal-epidermal junction. Marked mucin deposition was identified throughout the entire dermis, and dense, superficial and deep, perivascular and periadnexal lymphocytic infiltration were present. Direct immunofluorescence for the lupus band test was negative. Based on the above characteristic findings, the diagnosis of lupus erythematosus tumidus was made. Her eruptions improved after protection from sun exposure and treatment with topical steroids.