Does Glycation Stress Work as an Exercise-Resistance Factor?

Abstract

In the present study, to clear the possibility of glycation stress as an exercise-resistance factor, we investigated the effect of glycation stress on the molecules related to glucose metabolism and mitochondrial functions following to endurance exercise training in mice and on muscle power changes following resistance training in human. Four-week voluntary exercise training increased the expression levels of GLUT4, PGC1α, and HSP72 in mouse plantaris muscle. On the other hand, these changes were suppressed by the concomitant treatment of methylglyoxal, an inducer of glycation stress. In young male adults, the group in high-glycation stress showed lower leg muscle power output than that in low-glycation stress, but there was no difference between the two groups in the strength-enhancing effect of 12-week resistance training. In conclusion, it is suggested that glycation stress suppresses skeletal muscle adaptations induced by endurance exercise training and does not affect muscle power enhancement induced by resistance training.