Bone formation and osseointegration with titanium implant using granular- and block-type porous hydroxyapatite ceramics (IP-CHA)

Masahiko MINAMI; Masaaki TAKECHI; Kouji OHTA; Akira OHTA; Yoshiaki NINOMIYA; Megumi TAKAMOTO; Akiko FUKUI; Misato TADA; Nobuyuki KAMATA

doi:10.4012/dmj.2012-169

Original Paper

Bone formation and osseointegration with titanium implant using granular- and block-type porous hydroxyapatite ceramics (IP-CHA)

Masahiko MINAMI, Masaaki TAKECHI, Kouji OHTA, Akira OHTA, Yoshiaki NINOMIYA, Megumi TAKAMOTO, Akiko FUKUI, Misato TADA, Nobuyuki KAMATA

Author information

Masahiko MINAMI
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Masaaki TAKECHI
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Kouji OHTA
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Akira OHTA
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Yoshiaki NINOMIYA
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Megumi TAKAMOTO
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Akiko FUKUI
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Misato TADA
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University
Nobuyuki KAMATA
Departments of Oral and Maxillofacial Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University

Keywords: Interconnected porous hydroxyapatite ceramics (IP-CHA), Titanium implant, New bone formation

JOURNAL FREE ACCESS

2013 Volume 32 Issue 5 Pages 753-760

DOI https://doi.org/10.4012/dmj.2012-169

Details

Abstract

The aim of the present study was to examine whether interconnected porous hydroxyapatite ceramics (IP-CHA) could be used as bone substitute for implant treatment in reconstructive surgery. We firstly assessed if surround of the titanium surface placed into granular or block-type IP-CHA can observe new bone formation in a rabbit bone defect model. Subsequently, osseointegration and stability of titanium implant inserted into block-type IP-CHA was investigated in a rabbit onlay graft model. Direct contact between new bone and the surface of the titanium in granular- or block-type IP-CHA was found in a rabbit bone defect. Further, new bone formation was found in direct contact with the implant surface in the block-type IP-CHA in an onlay graft model, and the implant stability quotient (ISQ) values were significantly increased after surgery. Therefore, IP-CHA may be a useful material for implant treatment in reconstructive surgery strategies.

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