Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation

Kazuma KIYOTANI; Hiroshi YAMAZAKI; Masaki FUJIEDA; Satoshi DAIGO; Soisungwan SATARUG; Pailin UJJIN; Tetsuya KAMATAKI

doi:10.2133/dmpk.17.161

SNP Communications

Novel Mutations of the CYP2A6 Gene in a Thai Population with Lowered Capacity of Coumarin 7-Hydroxylation

Kazuma KIYOTANI, Hiroshi YAMAZAKI, Masaki FUJIEDA, Satoshi DAIGO, Soisungwan SATARUG, Pailin UJJIN, Tetsuya KAMATAKI

著者情報

キーワード: P450 2A6, genetic polymorphism, poor metabolizer, coumarin, silent mutation, 7-hydroxycoumarin

ジャーナルフリー

2002 年 17 巻 2 号 p. 161-163

DOI https://doi.org/10.2133/dmpk.17.161

詳細

抄録

  We explored genetic polymorphisms in a Thai population which exhibited a low capacity to metabolize coumarin. The following two silent single nucleotide polymorphisms (SNPs) were found:
  1) SNP, 020228Kiyotani001; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5′-AAACTACCTGCAG/TCTGAACACAGAG-3′.
  2) SNP, 020228Kiyotani002; GENE NAME, CYP2A6; ACCESSION NUMBER, NT_011139; LENGTH, 25 base; 5′-AATCCCCAGCAC/TTTCCTGAATGAG-3′.
  These two mutations (G144A and C1245T), which were located in exon 1 and exon 8 of the CYP2A6 gene, were found in two subjects among nine poor metabolizers for coumarin.

責任著者(Corresponding author)

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